Cell encapsulation in gelatin bioink impairs 3D bioprinting resolution

Recent advances in three-dimensional (3D) bioprinting technologies have enabled precise patterning of cellular components along with biomimetic constructs for tissue engineering and regenerative medicine. The viscoelasticity of bioinks regulate printability and the smallest feature size in 3D biopri...

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Bibliographic Details
Published inJournal of the mechanical behavior of biomedical materials Vol. 103; p. 103524
Main Authors Schwartz, Rachel, Malpica, Matthew, Thompson, Gary L., Miri, Amir K.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.03.2020
Subjects
3D bioprinting
Bioprinting
Cell Encapsulation
Gelatin
Hydrogels
Printability
Printing, Three-Dimensional
Resolution
Shear-thinning
Tissue Engineering
Tissue Scaffolds
Printability
Shear-thinning
3D bioprinting
Resolution
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Summary:Recent advances in three-dimensional (3D) bioprinting technologies have enabled precise patterning of cellular components along with biomimetic constructs for tissue engineering and regenerative medicine. The viscoelasticity of bioinks regulate printability and the smallest feature size in 3D bioprinted constructs. The impact of cellular components is typically neglected when choosing 3D bioprinting parameters. In this short communication, we quantified the effect of cell densities on the printability of hydrogel bioinks. Unexpectedly, our results show that encapsulated cells reduced the steady shear viscosity of gelatin-based bioinks by approximately 50% and the minimum force for onset of flow by approximately 30%. These results may justify the lower spatial resolution in 3D bioprinted cell-laden hydrogels.
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ISSN:1751-6161
1878-0180
DOI:10.1016/j.jmbbm.2019.103524