Fibrinolysis and antifibrinolytic drugs in the growth and spread of tumours

In the last few years increased release of fibrinolytic enzymes from malignant cells has been observed, but the significance of this property in relation to malignant growth is still not fully understood. Antifibrinolytic drugs decrease the growth rate of some experimental tumours and might have a s...

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Bibliographic Details
Published inCancer treatment reviews Vol. 4; no. 3; pp. 213 - 217
Main Author Peterson, Hans-Inge
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.09.1977
Subjects
Animals
Antifibrinolytic Agents - therapeutic use
Fibrin - metabolism
Fibrinolysis
Humans
Neoplasm Metastasis - drug therapy
Neoplasms - blood
Neoplasms - drug therapy
Neoplasms - physiopathology
Neoplastic Cells, Circulating
Plasminogen Activators - secretion
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Summary:In the last few years increased release of fibrinolytic enzymes from malignant cells has been observed, but the significance of this property in relation to malignant growth is still not fully understood. Antifibrinolytic drugs decrease the growth rate of some experimental tumours and might have a similar effect on human malignant tumours. Antifibrinolytic drugs might also decrease the intravascular shedding of tumour cells from primary tumours, but might on the other hand enhance the lodgement of those metastatic tumour cells already in the vascular bed of recipient organs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0305-7372
1532-1967
DOI:10.1016/S0305-7372(77)80025-X