Renin angiotensin involvement in transient hypertension after renal injury

Transient hypertension occurred in 3 patients shortly after blunt injury to the abdomen. Renal trauma was suspected in all 3 patients and radiological evidence for renal injury was present in 2. Plasma renin activity definitely was elevated in 1 patient and probably was elevated in another. There wa...

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Bibliographic Details
Published inThe Journal of urology Vol. 119; no. 4; p. 561
Main Authors Elias, A N, Anderson, Jr, G H, Dalakos, T G, Streeten, D H
Format Journal Article
LanguageEnglish
Published United States 01.04.1978
Subjects
Adult
Angiotensin II - metabolism
Blood Pressure
Humans
Hypertension - drug therapy
Hypertension - etiology
Hypertension - metabolism
Kidney - injuries
Male
Nitroprusside - therapeutic use
Renin - metabolism
Saralasin - therapeutic use
Wounds, Nonpenetrating - complications
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Summary:Transient hypertension occurred in 3 patients shortly after blunt injury to the abdomen. Renal trauma was suspected in all 3 patients and radiological evidence for renal injury was present in 2. Plasma renin activity definitely was elevated in 1 patient and probably was elevated in another. There was a decrease in blood pressure in all 3 patients during infusion of the angiotensin II analogue--saralasin--showing that the hypertension in these patients was angiotensin-mediated. Renal function as reflected by the blood urea nitrogen, creatinine and electrolytes was not impaired significantly. Thus, acute hypertension after blunt abdominal trauma may be angiotensinogenic and is not necessarily sustained.
ISSN:0022-5347
DOI:10.1016/S0022-5347(17)57548-5