Indoor air guide values for glycol ethers and glycol esters—A category approach

• Published in: International journal of hygiene and environmental health Vol. 219; no. 4-5; pp. 419 - 436
• Main Authors: Mangelsdorf, Inge, Kleppe, Sara Nordqvist, Heinzow, Birger, Sagunski, Helmut
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.07.2016
• Subjects: Air Pollutants - standards; Air Pollutants - toxicity; Air Pollution, Indoor; Animals; Category approach; Environmental Exposure - prevention & control; Esters - standards; Esters - toxicity; Ethers - standards; Ethers - toxicity; Glycol esters; Glycol ethers; Glycols - standards; Glycols - toxicity; Guide value; Humans; Indoor air; Maximum Allowable Concentration; Mice; Rabbits; Rats; Risk Assessment; Toxicity Tests; Toxicological databases; TTC; TTC; Glycol ethers; Toxicological databases; Glycol esters; Category approach; Guide value; Indoor air
• ISSN: 1438-4639; 1618-131X
• DOI: 10.1016/j.ijheh.2016.04.006

The German Committee on Indoor Guide Values issues indoor air guide values to protect public health. For health evaluation of glycol ethers and glycol esters in air, the entire group of substances with data for 47 chemicals was analyzed in order to gain a consistent assessment. For some glycol ethers reproductive and hematological effects are of central interest, whereas for others effects on liver and kidneys are crucial. Moreover, some glycol ethers have also been shown to cause irritation of the respiratory tract. For 14 chemicals, suitable inhalation studies were available for deriving specific guide values, or analogies to closely related substances could be drawn. For these chemicals individual indoor air guide values were derived, the respective guide value I ranging from 0.02 to 2mg/m3. Guide values were derived according to the procedures issued by the Committee, considering the exposure duration in indoor air compared to animal studies or the situation at workplaces, the duration of the respective study, species differences, and interindividual variability including special sensitivity of children. For glycol ethers with insufficient data default guide values II and I of 0.05 and 0.005ppm, respectively, were recommended based on statistical analyses of the available data on all glycol ethers and on evaluation of single studies. For evaluation of combined effects additivity is assumed.