Retinal manifestations of Alzheimer's disease

Alzheimer's disease (AD) is neurodegenerative condition and most common cause of dementia worldwide. Current criteria for its diagnosis and monitoring rely on subjective, expensive or invasive methods that lack sufficient sensitivity, such that a concrete diagnosis of AD can only be made postmo...

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Bibliographic Details
Published inNeurodegenerative disease management Vol. 4; no. 3; pp. 241 - 252
Main Authors Dehabadi, Mohammad H, Davis, Benjamin M, Wong, Timothy K, Cordeiro, M Francesca
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.06.2014
Subjects
Alzheimer Disease - diagnosis
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Alzheimer's disease
amyloid
Animals
detection of apoptozing retinal cells
Early Diagnosis
Humans
retina
Retina - pathology
Retina - physiopathology
retinal ganglion cell
tau
tau
amyloid
retina
Alzheimer's disease
detection of apoptozing retinal cells
retinal ganglion cell
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Summary:Alzheimer's disease (AD) is neurodegenerative condition and most common cause of dementia worldwide. Current criteria for its diagnosis and monitoring rely on subjective, expensive or invasive methods that lack sufficient sensitivity, such that a concrete diagnosis of AD can only be made postmortem. Given the structural similarities of the neuro-retina and central nervous system, researchers have shown many manifestations of AD to be detectible in the retinae of humans and transgenic models of AD. Due to the eye's unique optical properties allowing noninvasive imaging, the retina could provide a window for the early diagnosis and monitoring of AD long before symptom manifestation.
ISSN:1758-2024
1758-2032
DOI:10.2217/nmt.14.19