Nonspecific Signs and/or Symptoms of Cancer: A Retrospective, Observational Analysis from a Secondary Care, US Community Oncology Dataset

• Published in: Current oncology (Toronto) Vol. 31; no. 7; pp. 3643 - 3656
• Main Authors: Benton, Christopher B, He, Ding, Todoroff, Karen, Coignet, Marie V, Luan, Ying, Wong, Jason C, Kurtzman, Kathryn N, Zackon, Ira
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2024
• Subjects: Adult; Aged; Aged, 80 and over; Biotechnology industry; Cancer; cancer diagnosis; early detection; Female; Health aspects; Humans; Male; Medical records; Middle Aged; Neoplasms - epidemiology; nonspecific signs and/or symptoms; Oncology, Experimental; Retrospective Studies; Secondary Care; United States - epidemiology; United States; United Kingdom; nonspecific signs and/or symptoms; cancer diagnosis; early detection
• ISSN: 1718-7729; 1198-0052; 1718-7729
• DOI: 10.3390/curroncol31070268

To help determine the unmet need for improved diagnostic tools to evaluate patients with nonspecific signs and/or symptoms (NSSS) and suspicion of cancer, we examined patient characteristics, diagnostic journey, and cancer incidence of patients with NSSS within The US Oncology Network (The Network), a secondary care community oncology setting. This retrospective, observational cohort study included patients aged ≥40 years with ≥1 NSSS in their problem list at their first visit within The Network (the index date) between 1 January 2016 and 31 December 2020. Patients were followed longitudinally with electronic health record data for initial cancer diagnosis, new noncancer diagnosis, death, end of study observation period, or 12 months, whichever occurred first. Of 103,984 patients eligible for inclusion, 96,722 presented with only 1 NSSS at index date; 6537/103,984 (6.3%) were diagnosed with 1 primary cancer within 12 months after the index date; 3825/6537 (58.5%) with hematologic malignancy, and 2712/6537 (41.5%) with solid tumor. Among patients diagnosed with cancer (n = 6774), the median time to cancer diagnosis after their first visit within The Network was 5.13 weeks. This study provides a real-world perspective on cancer incidence in patients with NSSS referred to a secondary care setting and highlights the unmet need for improved diagnostic tools to improve cancer outcomes.