Acute mild traumatic brain injury is not associated with white matter change on diffusion tensor imaging

• Published in: Brain (London, England : 1878) Vol. 137; no. Pt 7; pp. 1876 - 1882
• Main Authors: ILVESMÄKI, Tero, LUOTO, Teemu M, HAKULINEN, Ullamari, BRANDER, Antti, RYYMIN, Pertti, ESKOLA, Hannu, IVERSON, Grant L, ÖHMAN, Juha
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2014
• Subjects: Adult; Adult and adolescent clinical studies; Age Factors; Anisotropy; Biological and medical sciences; Brain Injuries - pathology; Diffusion Tensor Imaging; Female; Humans; Injuries of the nervous system and the skull. Diseases due to physical agents; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nerve Fibers, Myelinated - pathology; Nervous system; Neuroimaging; Neurology; Neuropsychological Tests; Organic mental disorders. Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Statistics, Nonparametric; Trauma Severity Indices; Traumas. Diseases due to physical agents; Nervous system diseases; magnetic resonance imaging; Statistical analysis; traumatic brain injury; Medical imagery; Contusion; concussion; Head trauma; Nuclear magnetic resonance imaging; White matter; Diffusion tensor imaging; diffusion tensor imaging; statistical analysis
• ISSN: 0006-8950; 1460-2156
• DOI: 10.1093/brain/awu095

This study was designed to (i) evaluate the influence of age on diffusion tensor imaging measures of white matter assessed using tract-based spatial statistics; (ii) determine if mild traumatic brain injury is associated with microstructural changes in white matter, in the acute phase following injury, in a large homogenous sample that was carefully screened for pre-injury medical, psychiatric, or neurological problems; and (iii) examine if injury severity is related to white matter changes. Participants were 75 patients with acute mild traumatic brain injury (age = 37.2 ± 12.0 years, 45 males and 30 females) and 40 controls (age = 40.6 ± 12.2 yrs, 20 males and 20 females). Age effects were analysed by comparing control subgroups aged 31-40, 41-50, and 51-60 years against a group of 18-30-year-old control subjects. Widespread statistically significant areas of abnormal diffusion tensor measures were observed in older groups. Patients and controls were compared using age and gender as covariates and in age- and gender-matched subgroups. Subgroups of patients with more severe injuries were compared to age-and gender-matched controls. No significant differences were detected in patient-control or severity analyses (all P-value > 0.01). In this large, carefully screened sample, acute mild traumatic brain injury was not associated with diffusion tensor imaging abnormalities detectable with tract-based spatial statistics.