Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran
The skin-tumor-initiating abilities of various metabolites of benzo(a)pyrene (BP) were determined in mice by using a two-stage system of tumorigenesis. We previously reported that BP-7,8-dihydrodiol (± trans) was approximately as potent as BP, suggesting that it may be a proximate carcinogen, but th...
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Published in | Cancer letters Vol. 3; no. 1-2; pp. 23 - 30 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
01.01.1977
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Subjects | |
Online Access | Get full text |
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Summary: | The skin-tumor-initiating abilities of various metabolites of benzo(a)pyrene (BP) were determined in mice by using a two-stage system of tumorigenesis. We previously reported that BP-7,8-dihydrodiol (± trans) was approximately as potent as BP, suggesting that it may be a proximate carcinogen, but the alleged ultimate carcinogen of BP [BP-7,8-dihydrodiol-9,10-epoxide (anti)] was a weak tumor initiator (Cancer Lett. 2: 115, 1976). Because of its high reactivity, the tumor-initiating ability of the BP-7,8-dihydrodiol-9,10-epoxide (anti) was determined by using acetone, benzene, and tetrahydrofuran (THF) as the solvent vehicles. The ‘diol-epoxide’ of BP was found to be an effective tumor initiator when applied topically in THF. The effectiveness of the various vehicles for the ‘diol-epoxide’ was as follows: THF > benzene > acetone; however, acetone was the best solvent for BP tumor initiation. The BP-9,10-dihydrodiol and BP-3-hydroxy were found to be weak tumor initiators. BP-3-hydroxy was also tested for tumor-promoting ability and was found to be inactive in this capacity. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/S0304-3835(77)93845-9 |