Concentration of chromium in whole blood and erythrocytes showed different relationships with serum apolipoprotein levels in Cr(VI) exposed subjects

• Published in: Journal of trace elements in medicine and biology Vol. 50; pp. 384 - 392
• Main Authors: Feng, Huimin, Ha, Feizai, Hu, Guiping, Wu, Yonghua, Yu, Shanfa, Ji, Zhang, Feng, Weiyue, Wang, Tiancheng, Jia, Guang
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.12.2018
• Subjects: Adult; Apolipoproteins - blood; Chromium - blood; Chromium - toxicity; Cross-Sectional Studies; Element homeostasis; Erythrocytes - drug effects; Erythrocytes - metabolism; Female; Hexavalent chromium exposure; Homeostasis - drug effects; Humans; Male; Middle Aged; Serum lipoprotein metabolism; Young Adult; Serum lipoprotein metabolism; Element homeostasis; Hexavalent chromium exposure
• ISSN: 0946-672X; 1878-3252; 1878-3252
• DOI: 10.1016/j.jtemb.2018.08.003

To explore the effects of hexavalent chromium [Cr(VI)] on apolipoprotein(Apo) metabolism. One hundred and six long-term Cr(VI) exposed subjects and fifty five non-exposed individuals were recruited. The blood metals, glucose and lipid parameters were measured to evaluate the effects of hexavalent chromium on the apolipoproteins. The quantity and homeostasis of multi-elements were significantly different between Cr(VI)exposed subjects and the controls(P < 0.05). The levels of serum TG, FPG, LDL-C, Apo AI, AII, CII, CIII, E and Lp(a) also changed significantly (P < 0.05). Concentration of chromium in whole blood and erythrocytes had different relationships with serum apolipoprotein levels in Cr(VI)exposed subjects. Exposure of hexavalent chromium could significantly change the homeostasis of multi-elements as well as the levels of serum apolipoproteins. Cr(III) and Cr(VI)may have different effects on the apolipoproteins.