Synthesis of imidazo[1,2-a] annulated pyridines, pyrazines and pyrimidines by a novel three-component condensation

A novel three-component, one-pot condensation yielding 3-amino-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines and imidazo[1,2-a]pyrimidines from aldehydes, isonitriles and 2-amino-pyridine, 2-amino-pyrazine or 2-amino-pyrimidine is described.

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Bibliographic Details
Published inSynlett no. 6; pp. 661 - 664
Main Authors Groebke, K, Weber, L, Mehlin, F
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.06.1998
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
heterobicyclic compounds
multicomponent condensation
imidazopyrazines
Ugi reaction
PYRROLES
imidazopyridines
imidazopyrimidines
COMPOUND LIBRARIES
CONVERTIBLE ISOCYANIDE
PHASE
ZOLPIDEM
combinatorial chemistry
4-COMPONENT CONDENSATION
DERIVATIVES
BINDING
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Summary:A novel three-component, one-pot condensation yielding 3-amino-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines and imidazo[1,2-a]pyrimidines from aldehydes, isonitriles and 2-amino-pyridine, 2-amino-pyrazine or 2-amino-pyrimidine is described.
ISSN:0936-5214
DOI:10.1055/s-1998-1721