Single-Center Analysis of Pegfilgrastim-induced Aortitis Using a Drug Prescription Database and CT Findings

• Published in: Radiology Vol. 305; no. 3; pp. 729 - 740
• Main Authors: Takamatsu, Atsushi, Yoshida, Kotaro, Toshima, Fumihito, Kozaka, Kazuto, Yamamoto, Naho, Sai, Yoshimichi, Gabata, Toshifumi
• Format: Journal Article
• Language: English
• Published: United States 01.12.2022
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Aortitis - chemically induced; Aortitis - diagnostic imaging; Aortitis - drug therapy; Breast Neoplasms - drug therapy; Cisplatin - therapeutic use; Docetaxel - therapeutic use; Drug Prescriptions; Esophageal Neoplasms - drug therapy; Female; Filgrastim - adverse effects; Fluorouracil; Granulocyte Colony-Stimulating Factor - therapeutic use; Humans; Male; Middle Aged; Polyethylene Glycols - adverse effects; Retrospective Studies; Tomography, X-Ray Computed
• ISSN: 0033-8419; 1527-1315
• DOI: 10.1148/radiol.220357

Background Pegfilgrastim-induced aortitis is a rare but serious adverse event in patients undergoing anticancer therapy with granulocyte colony-stimulating factor analogs. Despite previous case series and systemic reviews, the exact incidence, clinical presentation, and CT manifestations of pegfilgrastim-induced aortitis remain unclear. Purpose To clarify the incidence and clinicoradiologic characteristics of pegfilgrastim-induced aortitis. Materials and Methods Pegfilgrastim administration records from January 2015 to March 2021 were retrospectively collected from the drug prescription database of a single center and were matched with the relevant findings in the CT database. Corresponding CT images within 6 months were available for a total of 1462 doses of pegfilgrastim in 674 patients. Four radiologists reviewed the CT images for the presence of aortitis in two steps. Clinical information and the distribution of aortitis on CT images were examined for patients with a diagnosis of pegfilgrastim-induced aortitis. Results Pegfilgrastim-induced aortitis was observed in 18 of 674 patients (mean age, 62 years ± 13 [SD]; 424 men), resulting in incidence rates of 2.7% per patient (95% CI: 1.6, 4.2) and 1.2% per dose (95% CI: 0.7, 1.9). The most common original primary malignancies were esophageal cancer ( = 10, 9%), breast cancer ( = 3, 4%), and pancreatic cancer ( = 2, 2%). The most common anticancer drugs used at onset were 5-fluorouracil, cisplatin, and docetaxel. Seven cases were symptomatic, while the remaining 11 (61%) were asymptomatic. CT findings indicated that aortitis involved branches of the aortic arch in 13 cases (72%), aortic arch in 10 cases (56%), and abdominal aorta in two cases (11%). Conclusion Pegfilgrastim-induced aortitis may be more prevalent than previously reported and may be more common in patients with esophageal cancer and those who received 5-fluorouracil, cisplatin, and docetaxel as anticancer drugs. The findings also suggest that pegfilgrastim-induced aortitis is often characterized by aortic arch and proximal branch involvement at CT. © RSNA, 2022 See also the editorial by Krinsky in this issue.