Dynamic Expression of Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel 4 Involved in Microwave Induced Pacemaker Cell Injuries

• Published in: Biomedical and environmental sciences Vol. 28; no. 11; pp. 823 - 828
• Main Authors: LIU, Yan Qing, ZHAO, Li, GAO, Ya Bing, DONG, Ji, WANG, Hui, YAO, Bin Wei, ZHOU, Hong Mei, WANG, Shui Ming, PENG, Rui Yun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2015
• Subjects: Animals; Animals, Newborn; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism; Male; Microwaves - adverse effects; Random Allocation; Rats, Wistar; Sinoatrial Node - metabolism; Sinoatrial Node - radiation effects; Wistar大鼠; 动态表; 微波诱导; 环核苷酸; 离子通道; 细胞损伤; 起搏; 门控
• ISSN: 0895-3988; 2214-0190
• DOI: 10.1016/S0895-3988(15)30113-6

To investigate the mechanisms of microwave induced pacemaker cell injuries, Wistar rats and the primary pacemaker cells of newborn Wistar rats were exposed to microwave at average power density of 50 mW/cm2. Slower spontaneous beating rate, intercellular Ca2＋ aggregation and cell membrane perforation were detected immediately after the exposure. Moreover, hyperpolarizationactivated cyclic nucleotide-gated cation channel 4 （HCN4） was down-regulated immediately after the exposure and up-regulated at 12 h after the exposure. In the sinoatrial node （SAN） of the rats,