Palladium-catalysed arylative cyclisation of N-allylacetamides with aryl halides yielding benzyl-substituted oxazolines

Treatment of N-allylacetamide with aryl halide in the presence of sodium t-butoxide and a palladium catalyst leads to arylative cyclisation to provide the corresponding benzyl-substituted oxazoline in high yield.

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Bibliographic Details
Published in	Chemical communications (Cambridge, England) no. 38; pp. 5754 - 5756
Main Authors	Fujino, Daishi, Hayashi, Sayuri, Yorimitsu, Hideki, Oshima, Koichiro
Format	Journal Article
Language	English
Published	CAMBRIDGE Royal Soc Chemistry 01.01.2009
Subjects	Acetamides - chemistry Catalysis catalysts catalytic activity chemical communication chemical reactions Chemistry Chemistry, Multidisciplinary Cyclization organic halogen compounds Oxazoles - chemical synthesis Oxazoles - chemistry palladium Palladium - chemistry Physical Sciences Science & Technology sodium Stereoisomerism CARBOAMINATION REACTIONS ALKENES ISOXAZOLIDINES ASYMMETRIC-SYNTHESIS ACID TETRAHYDROFURANS ONE-POT SYNTHESIS CARBOETHERIFICATION THIAZOLE STEREOSELECTIVE-SYNTHESIS
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ISSN	1359-7345 1364-548X 1364-548X
DOI	10.1039/b912895f

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Summary:	Treatment of N-allylacetamide with aryl halide in the presence of sodium t-butoxide and a palladium catalyst leads to arylative cyclisation to provide the corresponding benzyl-substituted oxazoline in high yield.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/b912895f