Potassium inwardly-rectifying channel subfamily J member 11 (KCNJ11) gene polymorphism in Egyptian type 2 diabetic patients: a single-center study

• Published in: Molecular biology reports Vol. 51; no. 1; p. 1129
• Main Authors: Abdelazem, Abdallah S., Gaber, Osama Abdelaziz, Hussein, Samia, Nasr, Fatma Mahmoud Elsaid, M. Elshorbagy, Eman A., Ibrahim, Sara Mohammed, Abdel-hameed, Abdullah Mohammad, Rashad, Mai Hamdy, El-Shal, Amal S., Abdelnabi, Al-Shabrawy M.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2024; Springer Nature B.V
• Subjects: Adult; Alleles; Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; Blood glucose; Blood Glucose - metabolism; Body mass index; Case-Control Studies; Cholesterol; clinical examination; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Egypt; family; Fasting; Female; Gene frequency; Gene Frequency - genetics; Gene polymorphism; Genetic diversity; Genetic Predisposition to Disease; Genotype; Glycated Hemoglobin - metabolism; glycohemoglobin; Hemoglobin; High density lipoprotein; Histology; Humans; insulin; KCNJ11 gene; Life Sciences; lipid composition; Low density lipoprotein; Male; Middle Aged; Morphology; noninsulin-dependent diabetes mellitus; Original Article; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide - genetics; Potassium; potassium channels; Potassium Channels, Inwardly Rectifying - genetics; regression analysis; risk; secretion; Single-nucleotide polymorphism; Statistical analysis; subfamily; Triglycerides; Egypt; Lipid profile; Diabetes mellitus; Genetic polymorphism
• ISSN: 0301-4851; 1573-4978; 1573-4978
• DOI: 10.1007/s11033-024-10035-4

Background The KCNJ11 gene belongs to the potassium channel gene family. It has a major role in the secretion of insulin. Genetic variations in KCNJ11 are possibly responsible for the progression of type 2 diabetes mellitus (T2DM). In this study, we investigated the possible correlation between KCNJ...