Restoration of calcium release synchrony: A novel target for heart failure and ventricular arrhythmia

Myocardial calcium (Ca ) signaling plays a crucial role in contractile function and membrane electrophysiology. An abnormal myocardial Ca transient is linked to heart failure and ventricular arrhythmias. At the subcellular level, the synchronous release of Ca sparks from sarcoplasmic Ca release unit...

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Bibliographic Details
Published inHeart rhythm Vol. 20; no. 12; pp. 1773 - 1781
Main Authors Chakraborty, Praloy, Aggarwal, Arjun K, Nair, Madhav Krishna Kumar, Massé, Stéphane, Riazi, Sheila, Nanthakumar, Kumaraswamy
Format Journal Article
LanguageEnglish
Published United States 01.12.2023
Subjects
Arrhythmias, Cardiac
Calcium - metabolism
Calcium Signaling - physiology
Heart Failure
Humans
Myocardium - metabolism
Myocytes, Cardiac - metabolism
Ryanodine Receptor Calcium Release Channel - metabolism
Sarcoplasmic Reticulum - metabolism
Calcium transient
RyR2 stabilization
Calcium release unit
Couplon
Ca(2+) release synchrony
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Summary:Myocardial calcium (Ca ) signaling plays a crucial role in contractile function and membrane electrophysiology. An abnormal myocardial Ca transient is linked to heart failure and ventricular arrhythmias. At the subcellular level, the synchronous release of Ca sparks from sarcoplasmic Ca release units determines the configuration and amplitude of the global Ca transient. This narrative review evaluates the role of aberrant Ca release synchrony in the pathophysiology of cardiomyopathies and ventricular arrhythmias. The potential therapeutic benefits of restoration of Ca release synchrony in heart failure and ventricular arrhythmias are also discussed.
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ISSN:1547-5271
1556-3871
1556-3871
DOI:10.1016/j.hrthm.2023.08.040