Evaluation of profile and functionality of memory T cells in pulmonary tuberculosis

• Published in: Immunology letters Vol. 192; pp. 52 - 60
• Main Authors: Tonaco, Marcela M., Moreira, Jôsimar D., Nunes, Fernanda F.C., Loures, Cristina M.G., Souza, Larissa R., Martins, Janaina M., Silva, Henrique R., Porto, Arthur Henrique R., Toledo, Vicente Paulo C.P., Miranda, Silvana S., Guimarães, Tânia Mara P.D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2017
• Subjects: Adult; Asymptomatic Diseases; CD27; CD4-Positive T-Lymphocytes - immunology; CD45RO; CD8-Positive T-Lymphocytes - immunology; Cells, Cultured; Female; Humans; IFN-ɣ; IL-2; IL17; Immunologic Memory; Immunophenotyping; Interferon-gamma - metabolism; Interleukin-17 - metabolism; Lung - immunology; Lung - microbiology; Lymphocytes; Male; Memory cells; Middle Aged; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; Surface markers; TNF-α; Tuberculosis; Tuberculosis, Pulmonary - immunology; Tumor Necrosis Factor-alpha - metabolism; Memory cells; IFN-ɣ; IL-2; TMC; IL17; LTBI; PBMC; TME; TB; IFN- ɣ; Tuberculosis; TNF-α; Mycobacterium tuberculosis; CD45RO; TBPT; Lymphocytes; IL-17; Mtb-Ags; CD27; Mtb; Surface markers; ATBP

•Patients with active pulmonary tuberculosis − highest proportion of cells T CD4+ TMC IFN-ɣ+ e TNF-α+.•LT CD4+TMC would be an important target of study for the development of more effective vaccines.•Patients after treatment of pulmonary TB − highest proportion of cells T CD4+ TMC IL-17+.•Individual...