Effect of Rosa damascena on improvement of adults’ sleep quality: a systematic review and meta-analysis of randomized controlled trials

• Published in: Sleep medicine Vol. 87; pp. 8 - 19
• Main Authors: Ghorbani Rami, Mohammad Sadegh, Nasiri, Morteza, Aghili Nasab, Mohammad Sadegh, Jafari, Zohre, Torkaman, Mahya, Feizi, Shahoo, Farahmandnia, Behnam, Asadi, Masoomeh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2021
• Subjects: Adult; Damask rose; Headache; Humans; Randomized Controlled Trials as Topic; Review; Rosa; Rosa damascena; Sleep; Sleep hygiene; Sleep Quality; Rosa damascena; Damask rose; Review; Sleep hygiene
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2021.07.017

Recent studies have reported inconclusive results regarding the potential effects of Rosa damascena on sleep quality. Therefore, this review aimed to summarize the findings of parallel-group and cross-over randomized controlled trials (RCTs) on the effects of aromatherapy and oral intake of Rosa damascena on adults’ sleep quality. The electronic data sources of PubMed, Scopus, Web of Science Core Collection, Embase, CENTRAL, ProQuest, CINAHL, SID, and MagIran were searched from inception to June 30, 2021. Out of 1341 publications found in the initial search, 10 RCTs were considered eligible for this review. The Cochrane risk-of-bias assessment tool was used to evaluate the risk of bias. Sufficient data were statistically pooled by a random-effects model using Stata software (version 11.2); otherwise, a narrative summary was presented. Based on the systematic review, the inhalation and oral intake of Rosa damascena could improve some sleep-related outcomes. The pooled analysis of seven effect sizes revealed that inhalation aromatherapy with Rosa damascena significantly improved sleep quality (standardized mean difference: 2.24; 95% confidence interval: 1.01–3.48; P < 0.001). Most RCTs had fair methodological quality, and two RCTs reported the adverse effects of treatment, including headache, nausea, vomiting, and frequent sneezing. The administration of Rosa damascena seems to be a promising approach in complementary and alternative medicine for the improvement of adults' sleep quality. However, considering the fair methodological quality of most RCTs and reported adverse effects, it is required to perform further high-quality RCTs to draw an evidence-based conclusion on the use of Rosa damascena for the improvement of adults’ sleep quality. CRD42020211778. •Inhalation aromatherapy with Rosa damascena significantly improved sleep quality.•Most included studies had fair methodological quality based on the Cochrane risk-of-bias assessment tool.•Two included studies reported the adverse effects of Rosa damascena.