A systematic review and meta-analysis of the effect of photodynamic therapy for the treatment of oral mucositis

• Published in: Photodiagnosis and photodynamic therapy Vol. 34; p. 102316
• Main Authors: de Oliveira, Analú Barros, Ferrisse, Túlio Morandin, Basso, Fernanda Gonçalves, Fontana, Carla Raquel, Giro, Elisa Maria Aparecida, Brighenti, Fernanda Lourenção
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2021
• Subjects: Oral mucositis; Photodynamic therapy; Systematic review, meta-analysis review; Systematic review, meta-analysis review; Oral mucositis; Photodynamic therapy
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2021.102316

[Display omitted] •PDT + LLLT is effective for oral mucositis healing process.•PDT + LLLT reduces the time of healing for oral mucositis than monotherapy.•Curcumin as a photosensitizer is effective in the oral mucositis treatment. Oral mucositis is a significant reaction to antineoplastic treatment characterized with pain, nutritional compromise, impact on the quality of life, interruption in cancer therapy and risk for infection. There is no effective standard protocol for the treatment of oral mucositis. This study aims to synthesize the scientific evidence available about the effects of photodynamic therapy on treatment of oral mucositis. PubMed, Scopus, Web of Science, Science Direct, Scielo, Embase and Cochrane libraries were searched. Two independent and calibrated researchers (kappa = 0.92) performed all systematic steps according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). To access the risk of bias, RoB 2 and Delphi list criteria for clinical trials were used. Meta-analysis was conducted using the R software with “META” package. Clinical and randomized clinical trials were included with a total of five articles. Meta-analysis, level of evidence, and risk of bias assessment were performed showing that photodynamic therapy was effective in reducing healing time in association with low-power laser therapy when compared to low-power laser therapy alone (p = 0.0005). Photodynamic therapy presents promising results for the treatment of oral mucositis. It may be an effective therapeutic option, contributing to the healing of injured tissues especially in the time needed for repair.