Chaotic activity during iron-induced 'epileptiform' discharge in rat hippocampal slices

• Published in: IEEE transactions on biomedical engineering Vol. 39; no. 11; pp. 1152 - 1160
• Main Authors: Koch, C.D., Palovcik, R.A., Uthman, B.M., Principe, J.C.
• Format: Journal Article
• Language: English
• Published: New York, NY IEEE 01.11.1992; Institute of Electrical and Electronics Engineers
• Subjects: Animals; Biological and medical sciences; Brain; Chaos; Circuits; Data Interpretation, Statistical; Electroencephalography; Epilepsy; Evoked Potentials - physiology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Hippocampus - physiopathology; Humans; In vitro; In Vitro Techniques; Iron; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Pattern recognition; Rats; Rhythm; Seizures - chemically induced; Seizures - physiopathology; Signal Processing, Computer-Assisted; Nervous system diseases; Rat; Rodentia; Exploration; Action potential; Iron; Epilepsy provoked by; Non linear system; Experimental study; In vitro; Biological activity; Thick section; Cerebral disorder; Electrodiagnosis; Dimensional model; Vertebrata; Mammalia; Neuron; Animal; Hippocampus
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/10.168694

Low-dimensional chaotic dynamics have been suggested in the rat hippocampal slice during iron-induced epileptiform activity. The dimensionality of this chaotic activity has been found to be similar in slices bathed in the same ionic extracellular medium. Some slices also displayed a drop in dimensionality prior to the onset of seizure-like activity. It is suggested that techniques of nonlinear dynamical analysis are a useful reverse-engineering tool for studying the in-vitro brain slice. The authors further conclude that neuronal circuits capable of displaying activity could exist at the level of the in vitro brain slice.< >