Functions and clinical implications of exosomes in pancreatic cancer

Pancreatic cancer is one of the most aggressive human malignancies and is associated with a dismal prognosis, which can be contributed to its atypical symptoms, metastatic propensity, and significant chemoresistance. Emerging evidence shows that pancreatic cancer cell-derived exosomes (PEXs) play cr...

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Published inBiochimica et biophysica acta. Reviews on cancer Vol. 1871; no. 1; pp. 75 - 84
Main Authors Qian, Ling, Yu, Shulin, Chen, Zhen, Meng, Zhiqiang, Huang, Shenglin, Wang, Peng
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2019
Subjects
Diagnosis
Drug delivery vehicle
Exosomes
Pancreatic cancer
Prognosis
Treatment
Treatment
Prognosis
Diagnosis
Exosomes
Drug delivery vehicle
Pancreatic cancer
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Summary:Pancreatic cancer is one of the most aggressive human malignancies and is associated with a dismal prognosis, which can be contributed to its atypical symptoms, metastatic propensity, and significant chemoresistance. Emerging evidence shows that pancreatic cancer cell-derived exosomes (PEXs) play critical roles in tumorigenesis and tumor development, as they are involved in drug resistance, immune evasion and metabolic reprograming, and distant metastasis of pancreatic cancer. Their numerous differentially expressed and functional contents make PEXs promising screening tools and therapeutic targets, which require further exploration. In this review, we focus on the functions of PEX contents and their clinical implications in pancreatic cancer.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0304-419X
1879-2561
DOI:10.1016/j.bbcan.2018.11.001