Fibrillar bodies in hepatocyte nuclei during the course of the toxic hepatitis produced by frog virus 3 in mice

• Published in: Journal of ultrastructure research Vol. 50; no. 2; pp. 167 - 173
• Main Authors: Bingen, Annick, Kirn, André
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01.02.1975
• Subjects: Animals; Anura - microbiology; Cell Nucleus - ultrastructure; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - pathology; Disease Models, Animal; DNA Viruses; Edetic Acid; Histocytochemistry; Inclusion Bodies - analysis; Inclusion Bodies - ultrastructure; Liver - ultrastructure; Mice; Mice, Inbred Strains; Microscopy, Electron; Pronase - metabolism; Proteins - analysis; Ribonucleases - metabolism

The presence of fibrillar bodies could be shown in the nuclei of mice hepatocytes during the very early stages of the toxic degenerative hepatitis produced by FV 3. These inclusions (1–10 per nucleus) which did not present any preferential localization in the nucleoplasm were composed of small filam...