Fibrillar bodies in hepatocyte nuclei during the course of the toxic hepatitis produced by frog virus 3 in mice

The presence of fibrillar bodies could be shown in the nuclei of mice hepatocytes during the very early stages of the toxic degenerative hepatitis produced by FV 3. These inclusions (1–10 per nucleus) which did not present any preferential localization in the nucleoplasm were composed of small filam...

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Bibliographic Details
Published inJournal of ultrastructure research Vol. 50; no. 2; pp. 167 - 173
Main Authors Bingen, Annick, Kirn, André
Format Journal Article
LanguageEnglish
Published United States Elsevier B.V 01.02.1975
Subjects
Animals
Anura - microbiology
Cell Nucleus - ultrastructure
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - pathology
Disease Models, Animal
DNA Viruses
Edetic Acid
Histocytochemistry
Inclusion Bodies - analysis
Inclusion Bodies - ultrastructure
Liver - ultrastructure
Mice
Mice, Inbred Strains
Microscopy, Electron
Pronase - metabolism
Proteins - analysis
Ribonucleases - metabolism
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Summary:The presence of fibrillar bodies could be shown in the nuclei of mice hepatocytes during the very early stages of the toxic degenerative hepatitis produced by FV 3. These inclusions (1–10 per nucleus) which did not present any preferential localization in the nucleoplasm were composed of small filaments from 7 to 8 nm in diameter. Histochemical studies revealed that the filaments were of proteinaceous nature. The significance of these inclusions is yet unknown, but their presence in the nucleoplasm, in addition to the very drastic alterations of the nucleus, bears further evidence of the nuclear toxicity of FV 3.
ISSN:0022-5320
1878-2345
DOI:10.1016/S0022-5320(75)80047-5