Clinical significance of PON1 L55M, Q192R and I102V polymorphisms and their association with prostate cancer risk in Polish men

We tested the association between PON1 L55M, Q192R and I102V polymorphic variants and PC risk in Polish men. DNA from 110 consecutive, newly diagnosed patients hospitalized because of PC and DNA from 110 men - volunteers, healthy at the time of the study. PCR-RFLP method. In our study the average ag...

Full description

Saved in:
Bibliographic Details
Published inPolish journal of pathology Vol. 71; no. 1; pp. 55 - 61
Main Authors Heise, Marta, Jarzemski, Piotr, Bąk, Aneta, Junkiert-Czarnecka, Anna, Pilarska-Deltow, Maria, Borysiak, Maciej, Haus, Olga
Format Journal Article
LanguageEnglish
Published Poland Termedia Publishing House 01.01.2020
Subjects
Age
Antioxidants
Cell cycle
clinical characteristics
Clinical significance
Deoxyribonucleic acid
Disease
DNA
Enzymes
Family medical history
Genes
Haplotypes
Mortality
Oxidative stress
Patients
Polymorphism
pon1 l55m
predisposition
Prostate cancer
Proteins
q192r and i102v polymorphisms
Survival analysis
Poland
Q192R and I102V polymorphisms
prostate cancer; PON1 L55M
predisposition
clinical characteristics
Online AccessGet full text

Cover

More Information
Summary:We tested the association between PON1 L55M, Q192R and I102V polymorphic variants and PC risk in Polish men. DNA from 110 consecutive, newly diagnosed patients hospitalized because of PC and DNA from 110 men - volunteers, healthy at the time of the study. PCR-RFLP method. In our study the average age at PC diagnosis of 55MM genotype carriers from families fulfilling Hereditary Prostate Criteria (HPC) was statistically significantly lower (by 7 years) than the average age at the disease diagnosis of 55MM carriers from families without HPC (54.6 ±6.7 vs. 61.9 ±5.4, respectively, p = 0.03). The probability of 5-year survival for the 55MM carriers was 81.3%, compared to 95.7% for non-carriers (p = 0.08, tendency). This is the first study in Polish men evaluating the impact of PON1 genetic polymorphisms on prostate cancer development and its clinical course. PON1 55MM variant may be probably associated with younger age at PC onset in men from families with HPC and with a shorter survival. However, more extensive studies on a larger number of PC patients, possibly from various populations, are necessary to confirm, and extend our findings.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1233-9687
2084-9869
DOI:10.5114/PJP.2020.95416