Sudden cardiac death and chronic kidney disease

Sudden cardiac death (SCD) is responsible for approximately one fourth of all cause mortality in dialysis patients. In chronic kidney disease (CKD) patients, unlike general population, traditional coronary artery disease associated risk factors are not the major determinants of SCD. The adverse card...

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Bibliographic Details
Published inAPIK Journal of Internal Medicine Vol. 11; no. 1; pp. 7 - 13
Main Author Jha, Vijoy
Format Journal Article
LanguageEnglish
Published Wolters Kluwer India Pvt. Ltd 01.01.2023
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
arrythmia
Cardiac arrest
cardiomyopathy
Chronic kidney failure
Coronary heart disease
Heart
hemodialysis
Mortality
Risk factors
sudden cardiac death
hemodialysis
Arrythmia
sudden cardiac death
cardiomyopathy
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Summary:Sudden cardiac death (SCD) is responsible for approximately one fourth of all cause mortality in dialysis patients. In chronic kidney disease (CKD) patients, unlike general population, traditional coronary artery disease associated risk factors are not the major determinants of SCD. The adverse cardiomyopathic and vasculopathic milieu in CKD predispose these patients to arrythmias, conduction abnormalities, and sudden cardiac death. In advanced kidney disease, these conditions may be further exacerbated by electrolyte shifts, divalent ion abnormalities, sympathetic overactivity, decreased baroreflex sensitivity, iron toxicity, and chronic inflammation. The outcomes after cardiac arrest in CKD patients particularly those on dialysis are poor. The decision to implant a cardioverter- defibrillator deppends on the patient's age and stage of CKD. In this review, we will discuss the definition, pathophysiology, risk factors and preventive strategies of SCD in the setting of CKD.
ISSN:2666-1802
2666-1802
DOI:10.4103/ajim.ajim_114_21