Risk Factors and On-site Rescue Treatments for Endoscopic Variceal Ligation Failure

• Published in: The Korean journal of gastroenterology Vol. 72; no. 4; pp. 188 - 196
• Main Authors: Kim, Dong Hyun, Cho, Eunae, Jun, Chung Hwan, Son, Dong Jun, Lee, Myeon Jae, Park, Chang Hwan, Cho, Sung Bum, Park, Seon-Young, Kim, Hyun Soo, Choi, Sung Kyu, Rew, Jong Sun
• Format: Journal Article
• Language: English
• Published: Korea (South) Jin Publishing & Printing Co 25.10.2018; 대한소화기학회
• Subjects: Adult; Aged; Aged, 80 and over; Case-Control Studies; Enbucrilate - therapeutic use; Esophageal and gastric varices; Esophageal and Gastric Varices - diagnosis; Esophageal and Gastric Varices - surgery; Esophagoscopy; Female; Gastrointestinal Hemorrhage - etiology; Gastrointestinal Hemorrhage - therapy; Humans; Ligation - adverse effects; Male; Middle Aged; Retrospective Studies; Risk Factors; Salvage Therapy; Treatment Failure; 내과학; Treatment failure; Salvage therapy; Esophageal and gastric varices
• ISSN: 1598-9992; 2233-6869
• DOI: 10.4166/kjg.2018.72.4.188

The success rate of endoscopic variceal ligation (EVL) is about 85-94%. There is only a few studies attempting to determine the cause of EVL failure, and to date, on-site rescue treatments remains unestablished. This study aimed to elucidate the risk factors for EVL failure and the effectiveness of on-site rescue treatment. Data of 454 patients who underwent emergency EVL at Chonnam National University Hospital were retrospectively analyzed. Enrolled patients were divided into two groups: the EVL success and EVL failure groups. EVL failures were defined as inability to ligate the varices due to poor endoscopic visual field, or failure of hemostasis after band ligation for the culprit lesion. Forty-seven patients experienced EVL failure. In the multivariate analysis, male patients, initial hypovolemic shock, active bleeding on endoscopy, and history of previous EVL were independent risk factors for EVL failure. During endoscopic procedure, we came across the common causes of EVL failure, including unsuctioned varix due to previous EVL-induced scars followed by insufficient ligation of the stigmata and inability to ligate the varix due to poor endoscopic visual field. Endoscopic variceal obturation using N-butyl-2-cyanoacrylate (48.9%) was the most commonly used on-site rescue treatment method, followed by insertion of Sangstaken Blakemore tube (14.9%), and EVL retrial (12.8%). The rescue treatments successfully achieved hemostasis in 91.7% of those in the EVL failure group. The risk factors of EVL failure should be considered before performing EVL, and in case of such scenario, on-site rescue treatment is needed.