An Improved Protocol for Palladium-Catalyzed Alkoxycarbonylations of Aryl Chlorides with Alkyl Formates

The palladium‐catalyzed alkoxycarbonylation of aryl and heteroaryl halides using butyl formate has been investigated. In the presence of palladium(II) acetate/n‐butylbis(1‐adamantyl)phosphine (L1), and 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) as base for the first time non‐activated chloroarenes can...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 352; no. 7; pp. 1205 - 1209
Main Authors Schareina, Thomas, Zapf, Alexander, Cotté, Alain, Gotta, Matthias, Beller, Matthias
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 03.05.2010
WILEY‐VCH Verlag
Wiley
Subjects
Acetates
alkoxycarbonylation
Aromatic compounds
aryl chlorides
carbon monoxide-free conditions
Carbonyls
Catalysis
Chemistry
Chemistry, Applied
Chemistry, Organic
Chlorides
Formates
Halides
palladium
Physical Sciences
Science & Technology
Synthesis
HETEROARYL BROMIDES
HALIDES
AMINOCARBONYLATIONS
aryl chlorides
carbon monoxide-free conditions
CARBONYLATION REACTIONS
COMPLEXES
HYDROXYLATION
catalysis
alkoxycarbonylation
FORMYLATION
EFFICIENT CATALYST
CARBON-MONOXIDE
palladium
ATMOSPHERIC-PRESSURE
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Summary:The palladium‐catalyzed alkoxycarbonylation of aryl and heteroaryl halides using butyl formate has been investigated. In the presence of palladium(II) acetate/n‐butylbis(1‐adamantyl)phosphine (L1), and 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) as base for the first time non‐activated chloroarenes can be conveniently carbonylated in good yields.
Bibliography:BMBF
Lanxess (Saltigo GmbH)
DFG
ark:/67375/WNG-ZVKRDSWB-K
State of Mecklenburg-Vorpommern
ArticleID:ADSC201000047
istex:AB35EFE25319DE75ED3544C9D7646AA926CF9C3F
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201000047