A Novel and Expedient Synthesis of 7-Pyrimidinylpyrimido[4,5-d]pyrimidinones

A novel and efficient procedure for the synthesis of new 7‐pyrimidinylpyrimido[4,5‐d]pyrimidinone derivatives was elaborated via the base‐promoted cyclodimerization reaction of 5‐[(dimethylamino)methylidene]‐6‐iminopyrimidine‐2,4(1H,3H)‐dione hydrochlorides. In an analogous manner, a 2‐thioxo analog...

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Bibliographic Details
Published inHelvetica chimica acta Vol. 93; no. 1; pp. 153 - 157
Main Authors Mohammadizadeh, Mohammad R., Bahramzadeh, Mojtaba, Mohammadi, Ali A., Karimi, Ali R.
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.01.2010
WILEY‐VCH Verlag
Wiley
Subjects
3H)-dione
4(1H
5-d]pyrimidinone derivatives
6-Aminouracil
6-imino
7-pyrimidinyl
Chemistry
Chemistry, Multidisciplinary
Cyclodimerization reactions
Physical Sciences
Pyrimidine-2
Pyrimidine‐2,4(1H,3H)‐dione, 6‐imino
Pyrimido
Pyrimido[4,5‐d]pyrimidinone derivatives, 7‐pyrimidinyl
Science & Technology
PYRIMIDINES
ANTITUMOR
INHIBITION
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Summary:A novel and efficient procedure for the synthesis of new 7‐pyrimidinylpyrimido[4,5‐d]pyrimidinone derivatives was elaborated via the base‐promoted cyclodimerization reaction of 5‐[(dimethylamino)methylidene]‐6‐iminopyrimidine‐2,4(1H,3H)‐dione hydrochlorides. In an analogous manner, a 2‐thioxo analog was prepared starting with the corresponding 2‐thioxopyrimidin‐4‐one.
Bibliography:istex:A25839D977EAA62C55A4296CBCDC0EA200E8DB97
ark:/67375/WNG-8BF5L0CB-N
ArticleID:HLCA200900183
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.200900183