Alteration in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV in quinolone-resistant clinical isolates of Staphylococcus epidermidis

We examined 22 clinical isolates of Staphylococcus epidermidis to analyze the association of alterations in GyrA and ParC with fluoroquinolone resistance. The simultaneous presence of GyrA and ParC alterations was associated with a high level of fluoroquinolone resistance in the clinical isolates of...

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Published inAntimicrobial agents and chemotherapy Vol. 42; no. 12; pp. 3293 - 3295
Main Authors ZHIYU LI, DEGUCHI, T, YASUDA, M, KAWAMURA, T, KANEMATSU, E, NISHINO, Y, ISHIHARA, S, KAWADA, Y
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.12.1998
SeriesNote
Subjects
4-Quinolones
Amino Acid Sequence
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II - genetics
DNA Topoisomerases, Type II - metabolism
Drug Resistance, Microbial
Mechanisms of Resistance
Medical sciences
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation
Pharmacology. Drug treatments
Polymerase Chain Reaction
Staphylococcus epidermidis
Staphylococcus epidermidis - drug effects
Staphylococcus epidermidis - enzymology
Staphylococcus epidermidis - genetics
DNA topoisomerase (ATP-hydrolysing)
Nucleotide sequence
Enzyme
In vitro
Polymerase chain reaction
Fluoroquinolone derivatives
Microorganism resistance
Isomerases
Staphylococcus epidermidis
Bacteria
Micrococcales
Micrococcaceae
Mutation
Quinolone derivatives
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Summary:We examined 22 clinical isolates of Staphylococcus epidermidis to analyze the association of alterations in GyrA and ParC with fluoroquinolone resistance. The simultaneous presence of GyrA and ParC alterations was associated with a high level of fluoroquinolone resistance in the clinical isolates of S. epidermidis.
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Corresponding author. Mailing address: Department of Urology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu City, Gifu 500-8705, Japan. Phone: 81-58-265-1241. Fax: 81-58-265-9009. E-mail: deguchit@cc.gifu-u.ac.jp.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.42.12.3293