Morphine administration selectively facilitates social play in common marmosets

Common marmosets (Callithrix jacchus) form extended families, and several cohorts of young may reside together. Play is shown extensively among the offspring. We hypothesized that opiate activity modulates social play, and predicted that administration of morphine (0.5 mg/kg) would facilitate social...

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Published inDevelopmental psychobiology Vol. 41; no. 1; pp. 37 - 49
Main Authors Guard, Heather J., Newman, John D., Roberts, R. Lucille
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.07.2002
Subjects
Analysis of Variance
Animals
Behavior, Animal - drug effects
Callithrix
common marmosets
Dose-Response Relationship, Drug
Female
juveniles
Male
morphine
Morphine - pharmacology
Motor Activity - drug effects
naloxone
Naloxone - pharmacology
Narcotic Antagonists - pharmacology
opiates
Play and Playthings
Premedication
Receptors, Opioid - administration & dosage
Sex Factors
Social Behavior
social play behavior
Time Factors
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Summary:Common marmosets (Callithrix jacchus) form extended families, and several cohorts of young may reside together. Play is shown extensively among the offspring. We hypothesized that opiate activity modulates social play, and predicted that administration of morphine (0.5 mg/kg) would facilitate social play, whereas pretreatment with naloxone (0.5 mg/kg) would block morphine's effects. Morphine administration was associated with significantly increased social play, and the effect of morphine was attributable to the focal subject, since play initiated by others was unaffected by treatment. Non‐social categories of play, such as object manipulation and locomotor play, and affiliative behaviors, such as time spent huddled, were unaffected by treatment. Twittering and play face, behaviors used by young during play, also increased after morphine administration. Pretreatment with naloxone blocked morphine's effects. Total activity was significantly increased by morphine administration. We conclude that social play is specifically facilitated by opiate activation, whereas other categories of play behavior and social behavior were unaffected by morphine. Thus, social play represents a distinct category of social behavior in juvenile common marmosets with regulatory processes that are unique from other types of social behavior. Published 2002 Wiley Periodicals, Inc. Dev Psychobiol 41: 37–49, 2002. Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/dev.10043
Bibliography:ark:/67375/WNG-FR9JZ9SF-H
We hereby certify that the standards followed in the care and use of animal subjects were approved by the Institutional Care and Use Committee of the National Institute of Child Health and Human Development in compliance with the NIH Guide for the Care and Use of Laboratory Animals. The NIH Animal Center is an AAALAC accredited facility.
This article is a US Government work, and, as such, is in the public domain in the United States of America.
istex:A73A459F0FA716B62C19D82CBFA797644DC8CB15
ArticleID:DEV10043
NIH Guide for the Care and Use of Laboratory Animals
We hereby certify that the standards followed in the care and use of animal subjects were approved by the Institutional Care and Use Committee of the National Institute of Child Health and Human Development in compliance with the
The NIH Animal Center is an AAALAC accredited facility.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0012-1630
1098-2302
DOI:10.1002/dev.10043