Histo-bacteriological Investigation on Borderline Tuberculoid Leprosy
The multi-sections, which were stained by Fite method, of skin biopsies taken from twelve active BT cases were examined under the guidance of special stains for demonstration of nerve components. All cases were AFB positive. Bacilli were found in infiltrated nerves in 11 cases, of which, in 7 cases,...
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| Published in | Japanese journal of leprosy Vol. 60; no. 3-4; pp. 152 - 157 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Japanese Leprosy Association
1991
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| Abstract | The multi-sections, which were stained by Fite method, of skin biopsies taken from twelve active BT cases were examined under the guidance of special stains for demonstration of nerve components. All cases were AFB positive. Bacilli were found in infiltrated nerves in 11 cases, of which, in 7 cases, bacilli were detected in nerve fragments within epithelioid cell granuloma. And bacilli were seen in arrector pill muscles in 2 cases. No bacilli were detected in other sites. Since the survival of M . leprae in nerves is one of the reasons causing relapse, this paper suggests that it would be better to treat active BT cases with multibacillary regimen recommended by WHO even though smear-negative |
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| AbstractList | The multi-sections, which were stained by Fite method, of skin biopsies taken from twelve active BT cases were examined under the guidance of special stains for demonstration of nerve components. All cases were AFB positive. Bacilli were found in infiltrated nerves in 11 cases, of which, in 7 cases, bacilli were detected in nerve fragments within epithelioid cell granuloma. And bacilli were seen in arrector pill muscles in 2 cases. No bacilli were detected in other sites. Since the survival of M . leprae in nerves is one of the reasons causing relapse, this paper suggests that it would be better to treat active BT cases with multibacillary regimen recommended by WHO even though smear-negative The multi-sections, which were stained by Fite method, of skin biopsies taken from twelve active BT cases were examined under the guidance of special stains for demonstration of nerve components. All cases were AFB positive. Bacilli were found in infiltrated nerves in 11 cases, of which, in 7 cases, bacilli were detected in nerve fragments within epithelioid cell granuloma. And bacilli were seen in arrector pili muscles in 2 cases. No bacilli were detected in other sites. Since the survival of M. leprae in nerves is one of the reasons causing relapse, this paper suggests that it would be better to treat active BT cases with multibacillary regimen recommended by WHO even though smear-negative. |
| Author | IZUMI, Shinzo KAWATSU, Kunio MAEDA, Yumi Butt, Khalid Iqbal WANG, Tiesheng |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/1726864$$D View this record in MEDLINE/PubMed |
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| References | 2) WHO Technical Report Series, No. 768, 1988. 3) Pattyn, S. R, et al.: Evaluation of five treatment regimens, using either dapsone monotherapy or several doses of rifampicin in the treatment of paucibacillary leprosy. Lepr. Rev., 61, 151-156(1990). 1) WHO Technical Report Series, No. 675, 1982. 4) Grugni, A. et al.: Relapses in paucibacillary leprosy after MDT-a clinical study. Int. J. Lepr. , 58, 19-24(1989). 7) Boerrigter, G. et al.: Four-year follow-up results of a WHO recommended multi-drugregimen in paucibacillary leprosy patients in Malawi. Int. J . Lepr., 59, 255-261(1990). 5) Brakel, W. V. et al.: Relapses after multidrug therapy for leprosy: a preliminary report of 22 cases in West Nepal. Lepr. Rev., 60, 45-50(1989). 9) Kawatsu, K.: Study on the histopathological stain of nerve fiber, influence of the combination of gelatin and silver in gelatin silver (in Japanese). Jap. J. Med. Photo., 29, 12-17(1991). 11) Ridley, D. S.: Pathology and bacteriology of early lesions in leprosy. Int. J. Lepr. , 39, 216 10) Ridley, D. S.: Skin biopsy in leprosy. 2nd. ed., Documenta Geigy., Basle(1985). 6) Katoch, K. et al.: Relapses in paucibacillary patients after treatment with three shortterm regimens containing rifampin. Int. J. Lepr., 57, 458-464(1988). 8) Ridley, D. S. & Jopling. W. H .: Classification of leprosy according to immunity, a fivegroup system. Int. J . Lepr. , 34, 255-273(1966). 12) Meyers, W. M.: Hansen's disease (HD) research: status 1990. The star., 50 (4), 2-5(1991). |
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| SubjectTerms | Acid-fast bacilli Humans Leprosy, Tuberculoid - microbiology Leprosy, Tuberculoid - pathology Nerve demonstration Paucibacillary leprosy Peripheral Nerves - microbiology Peripheral Nerves - pathology Recurrence Serial sections Skin - innervation Skin - microbiology Skin - pathology Staining and Labeling - methods |
| Title | Histo-bacteriological Investigation on Borderline Tuberculoid Leprosy |
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