Histo-bacteriological Investigation on Borderline Tuberculoid Leprosy

The multi-sections, which were stained by Fite method, of skin biopsies taken from twelve active BT cases were examined under the guidance of special stains for demonstration of nerve components. All cases were AFB positive. Bacilli were found in infiltrated nerves in 11 cases, of which, in 7 cases,...

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Bibliographic Details
Published inJapanese journal of leprosy Vol. 60; no. 3-4; pp. 152 - 157
Main Authors WANG, Tiesheng, Butt, Khalid Iqbal, MAEDA, Yumi, KAWATSU, Kunio, IZUMI, Shinzo
Format Journal Article
LanguageEnglish
Published Japan Japanese Leprosy Association 1991
Subjects
Acid-fast bacilli
Humans
Leprosy, Tuberculoid - microbiology
Leprosy, Tuberculoid - pathology
Nerve demonstration
Paucibacillary leprosy
Peripheral Nerves - microbiology
Peripheral Nerves - pathology
Recurrence
Serial sections
Skin - innervation
Skin - microbiology
Skin - pathology
Staining and Labeling - methods
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Summary:The multi-sections, which were stained by Fite method, of skin biopsies taken from twelve active BT cases were examined under the guidance of special stains for demonstration of nerve components. All cases were AFB positive. Bacilli were found in infiltrated nerves in 11 cases, of which, in 7 cases, bacilli were detected in nerve fragments within epithelioid cell granuloma. And bacilli were seen in arrector pill muscles in 2 cases. No bacilli were detected in other sites. Since the survival of M . leprae in nerves is one of the reasons causing relapse, this paper suggests that it would be better to treat active BT cases with multibacillary regimen recommended by WHO even though smear-negative
ISSN:0386-3980
2185-1360
DOI:10.5025/hansen1977.60.152