Melatonin controversies, an update

Melatonin was discovered more than 60 years ago. Since then, several seminal discoveries have allowed us to define its function as a neuroendocrine hormone and its molecular targets in mammals and many other species. However, many fundamental issues have not yet been solved such as the subcellular l...

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Bibliographic Details
Published inJournal of pineal research Vol. 70; no. 2; pp. e12702 - n/a
Main Authors Boutin, Jean A., Jockers, Ralf
Format Journal Article
LanguageEnglish
Published England Wiley 01.03.2021
Subjects
Alzheimer disease
Alzheimer Disease - drug therapy
Animals
antioxidant
Antioxidants
COVID-19 - drug therapy
COVID‐19
GPCR
Humans
Life Sciences
Melatonin
COVID-19
GPCR
antioxidant
melatonin
Alzheimer disease
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Summary:Melatonin was discovered more than 60 years ago. Since then, several seminal discoveries have allowed us to define its function as a neuroendocrine hormone and its molecular targets in mammals and many other species. However, many fundamental issues have not yet been solved such as the subcellular localization of melatonin synthesis and the full spectrum of its molecular targets. In addition, a considerable number of controversies persist in the field, mainly concerning how many functions melatonin has. Altogether, this illustrates how “immature” the field still is. The intention of this opinion article is to note the controversies and limitations in the field, to initiate a discussion and to make proposals/guidelines to overcome them and move the field forward.
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ISSN:0742-3098
1600-079X
DOI:10.1111/jpi.12702