From medications to surgery: advances in the treatment of motor complications in Parkinson's disease

• Published in: Drugs in Context Vol. 8; p. 212592
• Main Authors: Nagao, Kanae Jennifer, Patel, Neepa J
• Format: Journal Article
• Language: English
• Published: England BioExcel Publishing Ltd 2019
• Subjects: deep brain stimulation; levodopa; Parkinson’s disease; Review; therapy; levodopa; therapy; Parkinson’s disease; deep brain stimulation

Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have b...