From medications to surgery: advances in the treatment of motor complications in Parkinson's disease
Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have b...
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Published in | Drugs in Context Vol. 8; p. 212592 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
BioExcel Publishing Ltd
2019
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Subjects | |
Online Access | Get full text |
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Summary: | Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fluctuations and dyskinesia. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1745-1981 1740-4398 1740-4398 |
DOI: | 10.7573/dic.212592 |