From medications to surgery: advances in the treatment of motor complications in Parkinson's disease

Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have b...

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Published inDrugs in Context Vol. 8; p. 212592
Main Authors Nagao, Kanae Jennifer, Patel, Neepa J
Format Journal Article
LanguageEnglish
Published England BioExcel Publishing Ltd 2019
Subjects
deep brain stimulation
levodopa
Parkinson’s disease
Review
therapy
levodopa
therapy
Parkinson’s disease
deep brain stimulation
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Abstract Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fluctuations and dyskinesia.
AbstractList Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson’s disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fluctuations and dyskinesia.
Author Patel, Neepa J
Nagao, Kanae Jennifer
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CitedBy_id crossref_primary_10_1016_j_parkreldis_2020_10_042
crossref_primary_10_1016_j_parkreldis_2022_08_002
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crossref_primary_10_1111_ene_15992
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Keywords levodopa
therapy
Parkinson’s disease
deep brain stimulation
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Snippet Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of...
Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson’s disease (PD). The pulsatile nature of...
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SubjectTerms deep brain stimulation
levodopa
Parkinson’s disease
Review
therapy
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Title From medications to surgery: advances in the treatment of motor complications in Parkinson's disease
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