From medications to surgery: advances in the treatment of motor complications in Parkinson's disease

Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have b...

Full description

Saved in:
Bibliographic Details
Published inDrugs in Context Vol. 8; p. 212592
Main Authors Nagao, Kanae Jennifer, Patel, Neepa J
Format Journal Article
LanguageEnglish
Published England BioExcel Publishing Ltd 2019
Subjects
deep brain stimulation
levodopa
Parkinson’s disease
Review
therapy
levodopa
therapy
Parkinson’s disease
deep brain stimulation
Online AccessGet full text

Cover

More Information
Summary:Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fluctuations and dyskinesia.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1745-1981
1740-4398
1740-4398
DOI:10.7573/dic.212592