Secondary Metabolites from the Fungus Chaetomium brasiliense

Two new depsidones, mollicellins I and J (1 and 2, resp.), and a new chromone, 2‐(hydroxymethyl)‐6‐methylmethyleugenin (3), along with six known compounds, 4–9, were isolated from the ethyl acetate extract of a solid‐state fermented culture of Chaetomium brasiliense. Their structures were elucidated...

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Published inHelvetica chimica acta Vol. 91; no. 1; pp. 124 - 129
Main Authors Li, Guo-You, Li, Bo-Gang, Yang, Tao, Liu, Guang-Ye, Zhang, Guo-Lin
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.01.2008
WILEY‐VCH Verlag
Wiley
Subjects
Chaetomium brasiliense
Chemistry
Chemistry, Multidisciplinary
Chromones
Cytotoxic activity
Depsidones
Fungus
Metabolites
Mollicellins I and J
Physical Sciences
Science & Technology
CHAETOCIN
ASSAY
A-C
GLOBOSUM
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Summary:Two new depsidones, mollicellins I and J (1 and 2, resp.), and a new chromone, 2‐(hydroxymethyl)‐6‐methylmethyleugenin (3), along with six known compounds, 4–9, were isolated from the ethyl acetate extract of a solid‐state fermented culture of Chaetomium brasiliense. Their structures were elucidated based on spectroscopic analysis. Mollicellins I and H (5) exhibited significant growth inhibitory activity against human breast cancer (Bre04), human lung (Lu04), and human neuroma (N04) cell lines with GI50 values between 2.5–8.6 μg/ml.
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ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.200890002