Application of aqueous dispersions of silver nanostructures for treatment of pyoinflammatory diseases with a chronic component

• Published in: Journal of physics. Conference series Vol. 275; no. 1; pp. 012010 - 5
• Main Authors: Rutberg, Ph, Kolikov, V, Snetov, V, Stogov, A, Moshkin, A, Khalilov, M
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.01.2011
• Subjects: Antibiotics; Antiseptics; Cellular; Diseases; Dispersions; Electric charge; Electric discharges; Etiology; Medical services; Microorganisms; Nanostructure; Patients; Physics; Silver; Sodium hypochlorite
• ISSN: 1742-6596; 1742-6588; 1742-6596
• DOI: 10.1088/1742-6596/275/1/012010

Bactericidal properties of aqueous dispersions of oxide silver nanostructures (ADSN) produced by means of pulsed electric discharges (PED) in water can use in surgery for treatment of upper purulent wounds with a chronic component. The patients with such wounds are of large number and differ on etiology of diseases but their mutual feature is long treatment without marked positive changes. Thus long application of antibiotics leads to abnormality of immune processes and antibacterial resistance of microbial flora. Moreover, local antiseptics are frequently toxic and one can oppress processes of reparation in a wound. The investigation is addressed to finding out the opportunity of usage of an ADSN for treatment of purulent wounds with a chronic component and comparison of its efficiency with the sodium hypochlorite. At investigation, the ADSN formed at PED of 5 – 10 μs duration, with highest share of "small" (hydrodynamic diameter ≤ 100 nm) nanostructures and greatest surface electric charge we used. It was found that the usage of ADSN during the first 5 days characterized by high active reparative processes with their maximum at 3rd – 4th days and subsequent moderate further healing. At local use of ADSN, there were no cellular atypia and preternatural representations about inflammatory reactions. It is possible to assume that usage of ADSN will allow in prospect to correct the practice of out-patient therapy of chronic and slow pyoinflammatory diseases.