Lidocaine elimination: effects of metoprolol and of propranolol

The effects of administration of metoprolol and propranolol on lidocaine elimination were studied in six healthy young men who did not smoke. Each received three single intravenous doses of lidocaine (2.5 to 3.0 mg/kg injected over 10 min): one alone, one after 1 day pretreatment with propranolol (4...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 33; no. 2; p. 133
Main Authors Conrad, K A, Byers, 3rd, J M, Finley, P R, Burnham, L
Format Journal Article
LanguageEnglish
Published United States 01.02.1983
Subjects
Adult
Chromatography, Gas
Drug Interactions
Heart Rate - drug effects
Humans
Kinetics
Lidocaine - adverse effects
Lidocaine - metabolism
Male
Metoprolol - pharmacology
Propanolamines - pharmacology
Propranolol - pharmacology
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Summary:The effects of administration of metoprolol and propranolol on lidocaine elimination were studied in six healthy young men who did not smoke. Each received three single intravenous doses of lidocaine (2.5 to 3.0 mg/kg injected over 10 min): one alone, one after 1 day pretreatment with propranolol (40 mg orally every 6 hr), and one after 1 day pretreatment with metoprolol (50 mg orally every 6 hr). Lidocaine clearance was 0.88 +/- 0.28 l X hr-1 X kg-1 before beta blockade, 0.61 +/- 0.20 l X hr-1 X kg-1 during metoprolol dosing, and 0.47 +/- 0.16 l X hr-1 X kg-1 during propranolol dosing. There was no correlation between the change in lidocaine elimination and the steady-state concentrations of metoprolol or propranolol, nor between the change in lidocaine clearance and the change in resting heart rate produced by either beta blocker. Metoprolol and propranolol reduce lidocaine elimination significantly.
ISSN:0009-9236
DOI:10.1038/clpt.1983.20