A rare, in-frame BCR-ABL fusion (e13a3) in a patient with an aggressive chronic myeloid leukaemia

We have identified a rare BCR-ABL chimaeric gene with multiplex and nested RT-PCR in a patient with an unusually aggressive chronic myeloid leukaemia. cDNA sequencing showed an in-frame rearrangement with a breakpoint in BCR exon e13 (b2) and fusion with ABL exon 3 following skipping of the entire A...

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Bibliographic Details
Published inActa haematologica Vol. 108; no. 3; p. 150
Main Authors Otazú, Ivone B, Belén Rivero, María, Olício, Renata, Pinto, Augusto, Zalcberg, Ilana, Seuánez, Héctor N
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.2002
Subjects
Adult
Fusion Proteins, bcr-abl - genetics
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Male
Translocation, Genetic
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Summary:We have identified a rare BCR-ABL chimaeric gene with multiplex and nested RT-PCR in a patient with an unusually aggressive chronic myeloid leukaemia. cDNA sequencing showed an in-frame rearrangement with a breakpoint in BCR exon e13 (b2) and fusion with ABL exon 3 following skipping of the entire ABL exon a2. These data confirm the heterogeneity of breakpoints in BCR-ABL rearrangements.
ISSN:0001-5792
DOI:10.1159/000064701