The intrinsic and extrinsic elements regulating inflammation

• Published in: Life sciences (1973) Vol. 260; pp. 118258 - 14
• Main Authors: Mollaei, M., Abbasi, A., Hassan, Z.M., Pakravan, N.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.11.2020; Elsevier BV
• Subjects: Homeostasis; Inflammation; Intracellular signalling; Microbiome; Microbiota; NF-KB; NLRP3 inflammasome; Nutrition; Obesity; Physiology; Tissues; Obesity; Inflammation; Nutrition; NLRP3 inflammasome; NF-KB; Microbiome
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2020.118258

Inflammation is a sophisticated biological tissue response to both extrinsic and intrinsic stimuli. Although the pathological aspects of inflammation are well appreciated, there are still rooms for understanding the physiological functions of the inflammation. Recent studies have focused on mechanisms, context and the role of physiological inflammation. Besides, there have been progress in the comprehension of commensal microbiota, immunometabolism, cancer and intracellular signaling events' roles that impact on the regulation of inflammation. Despite the fact that inflammatory responses are vital through tissue damage, understanding the mechanisms to turn off the finished or unnecessary inflammation is crucial for restoring homeostasis. Inflammation seems to be a smart process that acts like two edges of a sword, meaning that it has both protective and deleterious consequences. Knowing both edges and the regulation processes will help the future understanding and therapy for various diseases. [Display omitted]