Antibacterial activity of fluoroquinolones in combination with zidovudine

• Published in: Journal of medical microbiology Vol. 33; no. 2; pp. 127 - 131
• Main Authors: LEWIN, C. S, ALLEN, RUTH A, AMYES, S. G. B
• Format: Journal Article
• Language: English
• Published: Reading Soc General Microbiol 01.10.1990; Society for General Microbiology
• Subjects: Action of physical and chemical agents on bacteria; AIDS/HIV; Anti-Infective Agents - administration & dosage; Bacteriology; Biological and medical sciences; Ciprofloxacin - administration & dosage; Dose-Response Relationship, Drug; Enoxacin - administration & dosage; Enterobacteriaceae - drug effects; Escherichia coli - drug effects; Fluoroquinolones; Fundamental and applied biological sciences. Psychology; Microbial Sensitivity Tests; Microbiology; Ofloxacin - administration & dosage; Pseudomonas aeruginosa - drug effects; Quinolones; Salmonella - drug effects; Staphylococcus - drug effects; Zidovudine - administration & dosage; Sensitivity; Minimum inhibitory concentration; Microorganism culture; Antiviral; Bacteria; Antibacterial agent; Biological activity
• ISSN: 0022-2615; 1473-5644
• DOI: 10.1099/00222615-33-2-127

Department of Bacteriology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG Received March 18, 1990 Accepted April 23, 1990 Since patients with AIDS may receive fluoroquinolones concurrently with zidovudine, the antibacterial interaction of these drugs was investigated. No evidence was found of antagonism between zidovudine and ciprofloxacin, DR-3355, enoxacin, lomefloxacin or ofloxacin against enterobacteria, staphylococci or Pseudomonas aeruginosa . Furthermore, the bactericidal activity of the fluoroquinolones against selected enterobacteria in nutrient broth was not affected by a clinically achievable concentration of zidovudine. It seems unlikely that zidovudine will have an adverse effect on the antibacterial activity of the fluoroquinolones in patients with AIDS.