First arch malformation: a new craniofacial mutant in the mouse

The first arch malformation arising in a BALB/c strain of mice, has been shown to be inherited as a single autosomal recessive gene and is given the provisional gene symbol far. Affected newborns have extensive bony defects of the face and skull, including a cleft secondary palate, and die within 24...

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Bibliographic Details
Published inThe Journal of heredity Vol. 71; no. 5; p. 331
Main Authors McLeod, M J, Harris, M J, Chernoff, G F, Miller, J R
Format Journal Article
LanguageEnglish
Published United States 01.09.1980
Subjects
Animals
Bone and Bones - pathology
Craniofacial Dysostosis - genetics
Craniofacial Dysostosis - pathology
Female
Genes, Recessive
Male
Mice
Mice, Inbred BALB C - genetics
Mutation
Palate - pathology
Phenotype
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Summary:The first arch malformation arising in a BALB/c strain of mice, has been shown to be inherited as a single autosomal recessive gene and is given the provisional gene symbol far. Affected newborns have extensive bony defects of the face and skull, including a cleft secondary palate, and die within 24 hours of birth. Most of the abnormalities occur in bones derived from the first branchial arch and most of the bony derivatives of the first arch are abnormal in the mutant.
ISSN:0022-1503
DOI:10.1093/oxfordjournals.jhered.a109381