Clinicopathologic characteristics of laryngeal chondrosarcoma: An analysis of the National Cancer Database

• Published in: Auris, nasus, larynx Vol. 48; no. 5; pp. 956 - 962
• Main Authors: Adeola, Janet O., Patel, Jimmy S., Povolotskiy, Roman, Barinsky, Gregory L., Grube, Jordon G., Hsueh, Wayne D., Baredes, Soly, Eloy, Jean Anderson
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2021
• Subjects: Bone Neoplasms - epidemiology; Bone Neoplasms - pathology; Bone Neoplasms - surgery; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuvant; Chondrosarcoma - epidemiology; Chondrosarcoma - pathology; Chondrosarcoma - surgery; Female; Humans; Laryngeal cancer; Laryngeal Cartilages - pathology; Laryngeal Cartilages - surgery; Laryngeal chondrosarcoma; Laryngeal malignancy; Laryngeal Neoplasms - epidemiology; Laryngeal Neoplasms - pathology; Laryngeal Neoplasms - surgery; Laryngeal tumor; Laryngectomy; Male; Middle Aged; NCDB; Neoplasm Grading; Neoplasm Staging; Proportional Hazards Models; Radiotherapy, Adjuvant; Sex Distribution; Laryngeal cancer; Laryngeal malignancy; NCDB; Laryngeal chondrosarcoma; Laryngeal tumor
• ISSN: 0385-8146; 1879-1476
• DOI: 10.1016/j.anl.2021.02.014

Laryngeal Chondrosarcoma (LC) is a rare malignancy with limited studies documenting its clinicopathologic characteristics and treatment options. This study reports demographic and clinical determinants of outcomes for this rare tumor. The National Cancer Database (NCDB) was queried for cases of LC reported from 2004–2016. 274 cases that met inclusion criteria were analyzed for demographic and clinicopathologic characteristics. Kaplan-Meier (KM) and Cox proportional hazard analyses were conducted to identify variables that impacted the overall survival of these patients. LC was found to be more common in males (74.8%). The mean age of patients was 61.8 years and 92.3% of the patients were white. 91.3% of patients were treated with only surgical resection, most commonly: partial laryngectomy (31.6%), total laryngectomy (25.7%), and local resection (22.4%). 98.8% of patients had no evidence of nodal disease and 99.6% of patients did not have distant metastasis at presentation. KM analysis revealed a 5-year overall survival (5YOS) of 89.0%. Age, insurance status, facility type, and surgery type were significant predictors of 5YOS (p<0.05). On Cox Proportional Hazard analysis, private insurance significantly improved survival (HR 0.21; p = 0.048) while increasing age was a poor prognostic indicator (HR 1.10; p = 0.004). The majority of LC patients present with no nodal involvement or distant metastasis at diagnosis, and overall this tumor has a favorable prognosis. Increasing age was found to be a poor prognostic factor while private insurance status was associated with improved survival.