Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers

In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechan...

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Bibliographic Details
Published inComposites. Part B, Engineering Vol. 121; pp. 58 - 67
Main Authors Grkovic, Mirjana, Stojanovic, Dusica B., Pavlovic, Vladimir B., Rajilic-Stojanovic, Mirjana, Bjelovic, Milos, Uskokovic, Petar S.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 15.07.2017
Subjects
Mechanical properties
Nano-structures
Polymer-matrix composites (PMCs)
Thermal properties
Thermal properties
Mechanical properties
Nano-structures
Polymer-matrix composites (PMCs)
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Summary:In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 °C antibacterial activity against Staphylococcus aureus and Escherichia coli, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.
ISSN:1359-8368
1879-1069
DOI:10.1016/j.compositesb.2017.03.024