Pedigree of the major histocompatibility complex in a family with a neonatal alloimmune thrombocytopenia

Immunization of a mother negative for the platelet-specific antigen P1A1 against the P1A1 antigen of her child induced neonatal alloimmune thrombocytopenia. This prompt immune response occurred in her first pregnancy and we were therefore interested to study whether there is an association with gene...

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Bibliographic Details
Published inBiology of the neonate Vol. 51; no. 4; p. 194
Main Authors Panzer, S, Kiefel, V, Mayr, W R, Fielder, A H, Lachmann, D, Mueller-Eckhardt, C
Format Journal Article
LanguageEnglish
Published Switzerland 1987
Subjects
Adult
Antibody Formation
Complement C2 - analysis
Complement C4 - analysis
Female
Haploidy
HLA Antigens - analysis
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
HLA-DR Antigens - analysis
Humans
Infant, Newborn
Major Histocompatibility Complex
Pedigree
Pregnancy
Thrombocytopenia - genetics
Thrombocytopenia - immunology
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Summary:Immunization of a mother negative for the platelet-specific antigen P1A1 against the P1A1 antigen of her child induced neonatal alloimmune thrombocytopenia. This prompt immune response occurred in her first pregnancy and we were therefore interested to study whether there is an association with genes located within the major histocompatibility complex. We deduced haplotypes of HLA-A, B, C and DR as well as of complement C2, C4 and Bf in the maternal family members.
ISSN:0006-3126
DOI:10.1159/000242651