Evoked potentials in multiple sclerosis before and after high-dose methylprednisolone infusion

• Published in: European neurology Vol. 25; no. 1; p. 67
• Main Authors: Smith, T, Zeeberg, I, Sjö, O
• Format: Journal Article
• Language: English
• Published: Switzerland 1986
• Subjects: Adult; Evoked Potentials - drug effects; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Female; Humans; Male; Median Nerve - physiopathology; Methylprednisolone - administration & dosage; Methylprednisolone - therapeutic use; Multiple Sclerosis - drug therapy; Multiple Sclerosis - physiopathology; Optic Neuritis - drug therapy; Optic Neuritis - physiopathology; Prospective Studies; Tibial Nerve - physiopathology
• ISSN: 0014-3022
• DOI: 10.1159/000115989

We studied 8 patients with definite multiple sclerosis (3 with acute relapse, 5 with progression), and 2 patients with acute optic neuritis, who were treated with methylprednisolone infusions, 1 g daily for 3 days. Visual, brain stem-auditory and somatosensory-evoked potentials were used to test the effect of therapy. There were no manifest changes of the evoked potentials parameters parallel to the clinical effect of high-dose therapy.