Induction of neoplasms in Egyptian toads Bufo regularis by oil of chenopodium

Feeding the Egyptian toad Bufo regularis with oil of the chenopodium plant induced hepatocellular carcinomas in 23% of the animals, and metastases of the primary liver tumors appeared in the kidneys of 6 toads. The earliest evidence of tumors appeared after 3 months of treatment. The average latent...

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Bibliographic Details
Published inOncology Vol. 49; no. 3; p. 253
Main Authors el-Mofty, M M, Khudoley, V V, Sakr, S A, Ganem, N F
Format Journal Article
LanguageEnglish
Published Switzerland 1992
Subjects
Animals
Anthelmintics - toxicity
Bufonidae - physiology
Carcinogens - toxicity
Disease Models, Animal
Female
Kidney Neoplasms - secondary
Liver Neoplasms - chemically induced
Male
Plant Oils - toxicity
Plants, Medicinal
Terpenes - toxicity
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Summary:Feeding the Egyptian toad Bufo regularis with oil of the chenopodium plant induced hepatocellular carcinomas in 23% of the animals, and metastases of the primary liver tumors appeared in the kidneys of 6 toads. The earliest evidence of tumors appeared after 3 months of treatment. The average latent period of tumor induction was 3.6 +/- 0.4 months. It is speculated that oil of chenopodium may be one of the constituents of Chenopodium ambrosoides which is responsible for tumor induction in the toads B. regularis.
ISSN:0030-2414
1423-0232
DOI:10.1159/000227050