Determination of platelet-megakaryocyte regeneration time in painters occupationally exposed to organic solvents

An improved method for the determination of the regeneration time of human platelets is presented. The platelet-megakaryocyte regeneration times of painters exposed to organic solvents ( n = 5; age range 23–48 years) were compared with a reference group ( n = 5; age range 23–46 years) not occupation...

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Published inJournal of chromatography Vol. 382; pp. 67 - 77
Main Authors Beving, H»kan, Kristensson, Jan, Malmgren, Rigmor, Olsson, Urban, Schmidt, Staffan, Svensson, Jan
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 1986
Subjects
Adult
Arachidonic Acid
Arachidonic Acids - blood
Aspirin - blood
Blood Platelets - drug effects
Blood Platelets - metabolism
Chromatography, High Pressure Liquid
Fatty Acids, Unsaturated - blood
Humans
Male
Megakaryocytes - drug effects
Megakaryocytes - metabolism
Middle Aged
Occupational Diseases - blood
Paint - adverse effects
Solvents - adverse effects
Spectrophotometry, Ultraviolet
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Summary:An improved method for the determination of the regeneration time of human platelets is presented. The platelet-megakaryocyte regeneration times of painters exposed to organic solvents ( n = 5; age range 23–48 years) were compared with a reference group ( n = 5; age range 23–46 years) not occupationally exposed to solvents. After purification and extraction of the samples, they were analysed by high-performance liquid chromatography. The results showed that the painters have a shorter regeneration time (range 4.4–5.2 days) than the reference group (range 5.2–6.9 days) and indicate that solvent exposure may be associated with an increase in platelet turnover in man.
ISSN:0378-4347
DOI:10.1016/S0378-4347(00)83505-7