Determination of platelet-megakaryocyte regeneration time in painters occupationally exposed to organic solvents
An improved method for the determination of the regeneration time of human platelets is presented. The platelet-megakaryocyte regeneration times of painters exposed to organic solvents ( n = 5; age range 23–48 years) were compared with a reference group ( n = 5; age range 23–46 years) not occupation...
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Published in | Journal of chromatography Vol. 382; pp. 67 - 77 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
1986
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Subjects | |
Online Access | Get full text |
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Summary: | An improved method for the determination of the regeneration time of human platelets is presented. The platelet-megakaryocyte regeneration times of painters exposed to organic solvents (
n = 5; age range 23–48 years) were compared with a reference group (
n = 5; age range 23–46 years) not occupationally exposed to solvents. After purification and extraction of the samples, they were analysed by high-performance liquid chromatography. The results showed that the painters have a shorter regeneration time (range 4.4–5.2 days) than the reference group (range 5.2–6.9 days) and indicate that solvent exposure may be associated with an increase in platelet turnover in man. |
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ISSN: | 0378-4347 |
DOI: | 10.1016/S0378-4347(00)83505-7 |