Generative Function of Female Rats Upon Intragastric Administration of Tablets of the New Steroid Drug Gestobutanoil

The generative function of female rats upon intragastric administration of tablets of gestobutanoil at doses of 0.25 and 2.5 mg/kg (calculated doses corresponding to the therapeutic dose and ten times higher) was studied. Gestobutanoil was administered two weeks before pregnancy, which corresponded...

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Published inPharmaceutical chemistry journal Vol. 54; no. 5; pp. 439 - 443
Main Authors Sheina, N. I., Parshin, V. A., Kolesnikova, V. V., Myalina, L. I., Sazonova, L. P., Fedotcheva, T. A., Shimanovskii, N. L.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2020
Springer
Subjects
Contraceptives
Health aspects
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pregnancy
offspring
generative function
gestobutanoil
pregnancy
estrous cycle
progestogen
steroid
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Summary:The generative function of female rats upon intragastric administration of tablets of gestobutanoil at doses of 0.25 and 2.5 mg/kg (calculated doses corresponding to the therapeutic dose and ten times higher) was studied. Gestobutanoil was administered two weeks before pregnancy, which corresponded to 2 – 3 estrous cycles. Gestobutanoil at a dose of 0.25 mg/kg exhibited progestogen activity. The duration of estrus, the fertility index, and the numbers of pregnancy corpus lutea and live fetuses increased in female rats. Administration of gestobutanoil at a dose of 2.5 mg/kg produced a contraceptive effect that manifested as a prolonged estrous cycle and a reduction of fertility and numbers of corpus lutea and fetuses. Gestobutanoil at both doses did not produce a teratogenic effect and did not affect the vitality of F1 offspring (survival, body-weight dynamics, sensory-motor behavior development).
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-020-02219-6